Setup Alerts for a SQL Server and then quickly copy those alerts to other SQL Servers by using the "Copy Config From Other Server" button.
Run Healthchecks for each newly connected SQL Server, looking for any orange colored warning rows in the results.
Review Blocking Queries - All active and blocking queries are saved once per minute so make sure to review each server's history
Find Slowest T-SQL statements and the slowest operator in each statement by using the "Top SQL" dashboards
Create Custom Alerts for your applications. Get alerted when your app encounters certain states by using the "Create Custom Alert" button on the alerts config screen.